Sex differences, diversity and equality

Historically, the assumption would be that many of these sex differences are to do with reproduction and reproductive strategies. That is indeed the case, and that’s what we’re finding. Even with our research in the gastrointestinal tract, we’re finding that male and female intestines are different. Many of these differences are to sustain reproductive output. So male and female flies or male and female mice will have different needs reproductive-wise, such as different nutritional needs. The gastrointestinal tract will adapt to those nutritional needs to deliver the kind of nutrients that the progeny will require.

Do sex differences also serve non-reproductive functions? That’s something that we’re beginning to explore, and I think the answer would probably be yes. There’s another question – a more difficult question that goes way beyond, research. But I think it’s a relevant question. As a woman in science, I also feel that it’s a question that we somehow need to address: do these sex differences matter for our society? As humans, we acknowledge that males and females are different. That’s something that is actually not widely acknowledged by the entire scientific community for reasons that we can discuss. But if we acknowledge that these differences exist, do they matter further away from a social perspective? And what do we do about them, how we deal with them as a society?

There are many layers in which we should consider sex differences. If you start from cells, as arguably the smallest functional unit, we are finding sex differences there. If we take human embryonic stem cells, we differentiate them. We make them turn into a particular cell type, and we look at the male ones. So those derived from males and those derived from females are different. We can catalogue those differences and we can describe those differences.

When these cells come together as tissues, say, an intestinal tube, that tissue is also different. So there are male guts and female guts. When you consider this three-dimensionally or at the level of the whole organism, there are differences, too. Now, I think that the tricky bit is to move from individual organisms to communities. That’s where it becomes controversial and where it becomes difficult, partly because what we normally describe as culture or nurture begins to interact with what we have so far only considered biology.

I think that dichotomy is a false dichotomy. It’s really difficult to separate nature from nurture because nurture will also be biologically encoded in some way. I think quite a few scientists would be happy with the idea that there are sex differences up to the individual level, and males and females are different in some ways, for example, in the way they reproduce. But equally, quite a few scientists would favour the idea that nurture overrides all these sex differences that are biologically determined.

I am not sure I agree with that idea. To me, it is not a particularly relevant discussion either, because I don’t see nature and nurture as two separate entities. In the end, I don’t think it’s particularly relevant to establish whether males and females differ and in what way. I think when we reach these kinds of societal issues, what we need to consider is that equality and diversity are two very different things.

In a way, the pandemic is a good example of this. For example, look at how we run countries and what we want our leaders to look like and behave like. We have this notion in our head that we want these strong leaders with a vision and confidence, who are going to take us somewhere. That’s how we elect our governments and that’s how we think we want to be led.

Yet I think this pandemic has shown that there’s a big difference between confidence and competence. What we should aspire to is to have some of our leaders be competent leaders, for example. Maybe in our definition or mindset we have underestimated those qualities. Now, when there’s an external challenge, the external challenge being the pandemic, we realise that having this very narrow definition of leadership is not particularly helpful.

Going back to the sex differences, these might be because of biological or environmental or societal reasons; they might be traits that are differentially represented between the sexes. Maybe trait A is more prevalent amongst males and trait B is more prevalent amongst females. I don’t particularly care whether this has happened as a result of biology or genetic factors, or whether it has happened as a result of societal expectations. The fact is, this trait might be differentially represented between males and females. We probably want a bit of both because we want to increase representation of all the traits, so that we can have a more robust and resilient leadership and society as a whole.

Historically, there are two ways to impart sex differences. One is what we call intrinsic to the cells. So these are genes that may be turned on and off differentially within cells, depending on whether they’re male or female. And they will impart some sort of sexual fate onto these cells. Historically, that was believed to be mainly the case in flies and insects, for example. They would have this kind of very intrinsic sex determination programme.

Then we go to the other end of the spectrum, and we considered ourselves, for example, or we considered mice, and the whole field was really dominated by hormones. You and I are different because I have oestrogen. You have testosterone. Then, it’s a little bit more complicated because both males and females have oestrogen and testosterone. But in any case, it was all about hormones, so my organs may be functioning in a female way and your organs may be functioning in a male way because they’re exposed to different sex hormones.

What we’re learning both in flies but also in mammals, possibly including humans, is that sexual fate is a combination of the two. You can have intrinsic programmes that masculinise your cells or feminise your cells. Those will co-exist with extrinsic signals that will also make them female or male.